VCY - variable charge Y-linked Gene

Homo sapiens

Also known as BPY1; VCY1; VCY1A

Gene ID: 9084 | Gene type: protein coding

About VCY

Cytogenetic location: Yq11.221 Genomic coordinates (GRCh38): Y:13,985,772-13,986,473 (from NCBI)

This gene has 1 transcript (splice variant), 28 orthologues, 5 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 20.6).

Summary

The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Jul 2008]

VCY Products(1)

mRNA	Protein	Name
NM_004679.4	NP_004670.1	testis-specific basic protein Y 1

Protein Preferred Names

Protein Names

testis-specific basic protein Y 1

basic charge, Y-linked 1

Related Diseases

Diseases

Alias

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked