RGN - regucalcin Gene

Homo sapiens

Also known as RC; GNL; SMP30; HEL-S-41

Gene ID: 9104 | Gene type: protein coding

About RGN

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,078,443-47,093,313 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Biased expression in liver (RPKM 68.0), adrenal (RPKM 65.2) and 11 other tissues.

Summary

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RGN Products(4)

mRNA	Protein	Name
NM_001282848.2	NP_001269777.1	regucalcin isoform 2
NM_001282849.2	NP_001269778.1	regucalcin isoform 3
NM_004683.6	NP_004674.1	regucalcin isoform 1
NM_152869.4	NP_690608.1	regucalcin isoform 1

RGN Protein Structure

SGL

0
100
200
299 a.a.

Protein Preferred Names

Protein Names

regucalcin

epididymis secretory protein Li 41

Related Diseases

Diseases

Alias

Aging

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11896	RGN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RGN	VGNC	VGNC:76912
Canis familiaris	RGN	VGNC	VGNC:45516
Felis catus	RGN	VGNC	VGNC:97604
Mus musculus	RGN	MGD	MGI:108024
Bos taurus	RGN	VGNC	VGNC:33907
Rattus norvegicus	RGN	RGD	RGD:3560
Others	RGN	NCBI