NEURL1 - neuralized E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Also known as neu; NEUR1; NEURL; RNF67; neu-1; bA416N2.1

Gene ID: 9148 | Gene type: protein coding

About NEURL1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,493,705-103,592,546 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.6), colon (RPKM 2.4) and 15 other tissues.

Summary

Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NEURL1 Products(1)

mRNA	Protein	Name
NM_004210.5	NP_004201.3	E3 ubiquitin-protein ligase NEURL1

NEURL1 Protein Structure

Neuralized

zf-C3HC4_3

0
100
200
300
400
500
574 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase NEURL1

RING finger protein 67

Related Diseases

Diseases

Alias

Malignant Astrocytoma

Astrocytic Tumor	Astrocytoma Of Brain
Astrocytoma Of Cerebrum	Astroglioma
Cerebral Astrocytoma	Astrocytoma

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Syndromic X-Linked Intellectual Disability Siderius Type

Mrxssd	Siderius-Hamel Syndrome
Siderius X-Linked Mental Retardation Syndrome

Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome	SCDO1
Vertebral Anomalies	Spondylothoracic Dysplasia
Costovertebral Dysplasia	Spondylothoracic Dysostosis
Spondylocostal Dysostosis 1	Autosomal Recessive Spondylocostal Dysostosis 1
Spondylocostal Dysostosis, Autosomal Recessive, 1	Doid:0112365
Dysostosis, Spondylocostal, Autosomal Recessive, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09219	NEURL1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS09220	NEURL1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NEURL1	MGD	MGI:1334263
Macaca mulatta	NEURL1	VGNC	VGNC:75319
Rattus norvegicus	NEURL1	RGD	RGD:1307021
Canis familiaris	NEURL1	VGNC	VGNC:43750
Felis catus	NEURL1	VGNC	VGNC:68463
Bos taurus	NEURL1	VGNC	VGNC:32013

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