2. Gene
  3. CD3E - CD3 epsilon subunit of T-cell receptor complex Gene

CD3E - CD3 epsilon subunit of T-cell receptor complex Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as T3E; TCRE; IMD18; CD3epsilon

Gene ID: 916 | Gene type: protein coding

About CD3E

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,304,730-118,316,173 (from NCBI)

This gene has 6 transcripts (splice variants), 121 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 92.6), appendix (RPKM 45.9) and 9 other tissues.

Summary

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

CD3E Products(1)

mRNA Protein Name
NM_000733.4 NP_000724.1 T-cell surface glycoprotein CD3 epsilon chain precursor

CD3E Protein Structure

ITAM

ITAM: Immunoreceptor tyrosine-based activation motif (185 - 205)

  • 0
  • 100
  • 207 a.a.
Protein Preferred Names Protein Names

T-cell surface glycoprotein CD3 epsilon chain

CD3-epsilon

Recombinant CD3E Proteins

Cat. No. Product Name Accession Purity
HY-P70434 CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His) P04234 (F22-A105)&P07766 (D23-D126) ≥95%
HY-P70506 CD3 epsilon Protein, Human (HEK293, His) P07766 (D23-D126) ≥95%
HY-P70682 CD3 epsilon Protein, Human (104a.a, HEK293, Fc) P07766 (D23-D126) ≥95%
HY-P70824 CD3 epsilon Protein, Human (27a.a, HEK293, Fc) P07766 (Q22-T48) ≥95%
HY-P72726 CD3D-CD3E Heterodimer Protein, Human (HEK293, His) P04234 (F22-A105)&P07766 (D23-D126) ≥95%
HY-P72357 CD3 epsilon Protein, Human (Biotinylated, HEK 293, Fc-Avi) P07766(D23-D126) ≥95%
HY-P73498 CD3D-CD3E Heterodimer Protein, Human (HEK293, Flag-His) P04234 (F22-A105)&P07766 (D23-D126) ≥95%
HY-P72899 CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc-Flag & mFc) P07766/NP_000724 (D23-D126) & P09693/NP_000064 (Q23-S116) ≥95%
HY-P74301 CD3D-CD3E Heterodimer Protein, Human (HEK293) P04234 (F22-A105)&P07766 (D23-D126) ≥95%
HY-P77609 CD3E-CD3G Heterodimer Protein, Human (HEK293, His) P07766 (D23-E120)&P09693 (Q23-Q106) ≥95%
HY-P77610 CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc) P04234 (F22-A105)&P07766 (D23-D126) ≥95%
HY-P77611 CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc) P07766 (D23-D126)&P09693 (Q23-S116) ≥95%
HY-P77612 CD3D-CD3E Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi) P04234 (F22-A105)&P07766 (D23-D126) ≥95%
HY-P77613 CD3E-CD3G Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi) P07766 (D23-D126)&P09693 (Q23-S116) ≥95%
HY-P78089 CD3 epsilon 1-27 peptide Protein, Human (Biotinylated, HEK293, His-Avi) P07766 (D23-T48) ≥95%
HY-P78873 CD3 epsilon Protein, Human (Biotinylated, HEK293, His-Avi) P07766 (D23-D126) ≥95%
HY-P78874 CD3 epsilon Protein, Human (Biotinylated, HEK293, His, solution) P07766/NP_000724.1 (D23-D126) ≥95%

Related Diseases

Diseases Alias
Immunodeficiency 18

IMD18

Cd3-Epsilon Deficiency

Immunodeficiency 18, Scid Variant

Cd3epsilon Deficiency

Immunodeficiency 18, Severe Combined Immunodeficiency Variant

Immunodeficiency, Type 18
T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta

T-B+ Scid Due To Cd3delta/Cd3epsilon/Cd3zeta
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99332 Visilizumab Inducer 98.43% Phase 3
HY-P99868 Duvortuxizumab / Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02243 CD3E Human Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990095 Vonsetamig Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CD3E VGNC VGNC:27029
Canis familiaris CD3E VGNC VGNC:38955
Mus musculus CD3E MGD MGI:88332
Felis catus CD3E VGNC VGNC:81992
Rattus norvegicus CD3E RGD RGD:1309222
Macaca mulatta CD3E VGNC VGNC:70764
Macaca fascicularis CD3E NCBI
Others CD3E NCBI