CD3G - CD3 gamma subunit of T-cell receptor complex Gene

Homo sapiens

Also known as T3G; IMD17; CD3GAMMA; CD3-GAMMA

Gene ID: 917 | Gene type: protein coding

About CD3G

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,344,344-118,355,161 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues.

Summary

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

CD3G Products(1)

mRNA	Protein	Name
NM_000073.3	NP_000064.1	T-cell surface glycoprotein CD3 gamma chain precursor

CD3G Protein Structure

ITAM

0
100
182 a.a.

Protein Preferred Names

Protein Names

T-cell surface glycoprotein CD3 gamma chain

CD3g antigen, gamma polypeptide (TiT3 complex)

Recombinant CD3G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77609	CD3E-CD3G Heterodimer Protein, Human (HEK293, His)	P07766 (D23-E120)&P09693 (Q23-Q106)	≥95%
HY-P77611	CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc)	P07766 (D23-D126)&P09693 (Q23-S116)	≥95%
HY-P77613	CD3E-CD3G Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi)	P07766 (D23-D126)&P09693 (Q23-S116)	≥95%
HY-P78753	CD3 gamma Protein, Human (HEK293, Fc)	P09693 (Q23-S116)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Immunodeficiency 18

IMD18	Cd3-Epsilon Deficiency
Immunodeficiency 18, Scid Variant	Cd3epsilon Deficiency
Immunodeficiency 18, Severe Combined Immunodeficiency Variant	Immunodeficiency, Type 18

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

Cd3zeta Deficiency

Lymphopenia

Lymphocytopenia

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02244	CD3G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD3G	MGD	MGI:88333
Canis familiaris	CD3G	VGNC	VGNC:38957
Rattus norvegicus	CD3G	RGD	RGD:1307718
Felis catus	CD3G	VGNC	VGNC:60617
Bos taurus	CD3G	VGNC	VGNC:27031
Macaca mulatta	CD3G	VGNC	VGNC:100904
Macaca fascicularis	CD3G	NCBI
Others	CD3G	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.