OTOP2 - otopetrin 2 Gene

Homo sapiens

Gene ID: 92736 | Gene type: protein coding

About OTOP2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,924,273-74,933,912 (from NCBI)

This gene has 3 transcripts (splice variants), 247 orthologues and 2 paralogues. Biased expression in colon (RPKM 10.3), testis (RPKM 1.8) and 1 other tissue.

Summary

Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

OTOP2 Products(1)

mRNA	Protein	Name
NM_178160.3	NP_835454.1	proton channel OTOP2

OTOP2 Protein Structure

Otopetrin

0
100
200
300
400
500
562 a.a.

Protein Preferred Names

Protein Names

proton channel OTOP2

Related Diseases

Diseases

Alias

Vertigo, Benign Recurrent

Benign Paroxysmal Positional Vertigo	Bppv
Vestibulopathy, Familial	BRV
Vertigo, Benign Paroxysmal Positional	Benign Paroxysmal Positional Nystagmus
Benign Recurrent Vertigo	Familial Benign Recurrent Vertigo
Familial Vestibulopathy	Benign Paroxysmal Nystagmus
Bppv - [Benign Positional Paroxysmal Vertigo]

Diversion Colitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09865	OTOP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	OTOP2	VGNC	VGNC:63996
Macaca mulatta	OTOP2	VGNC	VGNC:104639
Mus musculus	OTOP2	MGD	MGI:2388365
Bos taurus	OTOP2	VGNC	VGNC:32489
Rattus norvegicus	OTOP2	RGD	RGD:1304830

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