DRC1 - dynein regulatory complex subunit 1 Gene

Homo sapiens

Also known as CILD21; C2orf39; CCDC164

Gene ID: 92749 | Gene type: protein coding

About DRC1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,401,920-26,456,711 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues, 1 paralogue and is associated with 4 phenotypes. Restricted expression toward testis (RPKM 14.3).

Summary

This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015]

DRC1 Products(1)

mRNA	Protein	Name
NM_145038.5	NP_659475.2	dynein regulatory complex protein 1

DRC1 Protein Structure

NYD-SP28

NYD-SP28_assoc

0
200
400
600
740 a.a.

Protein Preferred Names

Protein Names

dynein regulatory complex protein 1

coiled-coil domain-containing protein 164

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 21

CILD21	Primary Ciliary Dyskinesia 21
Primary Ciliary Dyskinesia 21 Without Situs Inversus	Ciliary Dyskinesia, Primary, 21, Without Situs Inversus
Dyskinesia, Ciliary, Primary, 21

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Non-Syndromic Male Infertility Due To Sperm Motility Disorder

Non-Syndromic Male Infertility Due Asthenozoospermia

Ciliary Dyskinesia, Primary, 27

Primary Ciliary Dyskinesia 27	CILD27
Ciliary Dyskinesia, Primary, 27, Without Situs Inversus	Primary Ciliary Dyskinesia 27 Without Situs Inversus
Primary Ciliary Dyskinesia 27 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, 27

Kartagener Syndrome

Kartagener'S Syndrome

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Ciliary Dyskinesia, Primary, 4

Primary Ciliary Dyskinesia 4	CILD4
Ciliary Dyskinesia, Primary, 4, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 4 With Or Without Situs Inversus
Primary Ciliary Dyskinesia, 4

Ciliary Dyskinesia, Primary, 8

Primary Ciliary Dyskinesia 8	CILD8
Ciliary Dyskinesia, Primary, 8, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 8 With Or Without Situs Inversus

Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]

Suppurative Otitis Media

Otitis Media With Effusion - Purulent	Purulent Otitis Media
Otitis Media, Suppurative

Dextrocardia

Heart Predominantly In Right Hemithorax	Heart In Right Chest
Right-Sided Heart	Congenital Dextrocardia Of Heart
Transposition Of Heart

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03991	DRC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DRC1	VGNC	VGNC:28205
Macaca mulatta	DRC1	VGNC	VGNC:71892
Felis catus	DRC1	VGNC	VGNC:61623
Mus musculus	DRC1	MGD	MGI:2685906
Rattus norvegicus	DRC1	RGD	RGD:1359318
Canis familiaris	DRC1	VGNC	VGNC:40091
Others	DRC1	NCBI