2. Gene
  3. NAPRT - nicotinate phosphoribosyltransferase Gene

NAPRT - nicotinate phosphoribosyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NAPRT1; PP3856

Gene ID: 93100 | Gene type: protein coding

About NAPRT

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,572,874-143,578,330 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 188 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 19.1), small intestine (RPKM 16.7) and 25 other tissues.

Summary

Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]

NAPRT Products(4)

mRNA Protein Name
NM_001286829.2 NP_001273758.1 nicotinate phosphoribosyltransferase isoform 2
NM_001363145.1 NP_001350074.1 nicotinate phosphoribosyltransferase isoform 3
NM_001363146.1 NP_001350075.1 nicotinate phosphoribosyltransferase isoform 4
NM_145201.6 NP_660202.3 nicotinate phosphoribosyltransferase isoform 1

NAPRT Protein Structure

NAPRTase

NAPRTase: Nicotinate phosphoribosyltransferase (NAPRTase) family (164 - 219)

NAPRTase

NAPRTase: Nicotinate phosphoribosyltransferase (NAPRTase) family (284 - 416)

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  • 538 a.a.
Protein Preferred Names Protein Names

nicotinate phosphoribosyltransferase

FHA-HIT-interacting protein

Related Diseases

Diseases Alias
Pellagra

Niacin Deficiency

Niacin-Tryptophan Deficiency

Pellagroid Syndrome
Facial Dermatosis

Facial Dermatoses
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09033 NAPRT Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NAPRT VGNC VGNC:31885
Mus musculus NAPRT MGD MGI:2442664
Macaca mulatta NAPRT VGNC VGNC:75057
Canis familiaris NAPRT VGNC VGNC:43623
Rattus norvegicus NAPRT RGD RGD:1302945
Felis catus NAPRT VGNC VGNC:63722