KCNB2 - potassium voltage-gated channel subfamily B member 2 Gene

Homo sapiens

Also known as KV2.2

Gene ID: 9312 | Gene type: protein coding

About KCNB2

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:72,537,225-72,938,349 (from NCBI)

This gene has 1 transcript (splice variant), 235 orthologues and 31 paralogues. Low expression observed in reference dataset.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related Potassium Channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the Potassium Channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier Potassium Channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]

KCNB2 Products(1)

mRNA	Protein	Name
NM_004770.3	NP_004761.2	potassium voltage-gated channel subfamily B member 2

KCNB2 Protein Structure

BTB_2

Ion_trans

Kv2channel

0
200
400
600
800
911 a.a.

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily B member 2

delayed rectifier potassium channel protein

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 26

DEE26	Epileptic Encephalopathy, Early Infantile, 26
Eiee26	Early Infantile Epileptic Encephalopathy 26
Developmental And Epileptic Encephalopathy, 26	Encephalopathy, Epileptic, Early Infantile, Type 26

Extragonadal Germ Cell Cancer

Extragonadal Germ Cell Tumor	Extragonadal Germ Cell Malignant Tumor
Neoplasm Of Extragonadal Germ Cell	Tumor Of Extragonadal Germ Cell

Spinocerebellar Ataxia 13

Spinocerebellar Ataxia Type 13	SCA13
Autosomal Dominant Cerebellar Ataxia With Intellectual Disability	Cerebellar Ataxia, Autosomal Dominant With Intellectual Disability
Spinocerebellar Ataxia-13	Ataxia, Spinocerebellar, Type 13

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07107	KCNB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KCNB2	VGNC	VGNC:67898
Bos taurus	KCNB2	VGNC	VGNC:30431
Macaca mulatta	KCNB2	VGNC	VGNC:73970
Rattus norvegicus	KCNB2	RGD	RGD:621349
Mus musculus	KCNB2	MGD	MGI:99632

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