2. Gene
  3. NDST3 - N-deacetylase and N-sulfotransferase 3 Gene

NDST3 - N-deacetylase and N-sulfotransferase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSST3

Gene ID: 9348 | Gene type: protein coding

About NDST3

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:118,033,322-118,258,634 (from NCBI)

This gene has 2 transcripts (splice variants), 330 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded Enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional Enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]

NDST3 Products(1)

mRNA Protein Name
NM_004784.3 NP_004775.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

NDST3 Protein Structure

HSNSD

HSNSD: heparan sulfate-N-deacetylase (20 - 506)

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (596 - 844)

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  • 873 a.a.
Protein Preferred Names Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

GlcNAc N-deacetylase/ N-sulfotransferase 3

Related Diseases

Diseases Alias
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09120 NDST3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NDST3 VGNC VGNC:68436
Bos taurus NDST3 VGNC VGNC:53768
Macaca mulatta NDST3 VGNC VGNC:75152
Mus musculus NDST3 MGD MGI:1932544
Canis familiaris NDST3 VGNC VGNC:43683
Rattus norvegicus NDST3 RGD RGD:1310960