CXCL14 - C-X-C motif chemokine ligand 14 Gene

Homo sapiens

Also known as KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14

Gene ID: 9547 | Gene type: protein coding

About CXCL14

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,570,679-135,578,991 (from NCBI)

This gene has 2 transcripts (splice variants) and 194 orthologues. Biased expression in skin (RPKM 295.1), kidney (RPKM 161.0) and 13 other tissues.

Summary

This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

CXCL14 Products(1)

mRNA	Protein	Name
NM_004887.5	NP_004878.3	C-X-C motif chemokine 14 precursor

CXCL14 Protein Structure

IL8

0
100
111 a.a.

Protein Preferred Names

Protein Names

C-X-C motif chemokine 14

CXC chemokine in breast and kidney

Recombinant CXCL14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72683	CXCL14/BRAK Protein, Human	O95715 (S35-E111)	≥95%
HY-P75315	CXCL14/BRAK Protein, Human (Biotinylated)	O95715 (S35-E111)	≥95%

Related Diseases

Diseases

Alias

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03388	CXCL14 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CXCL14	VGNC	VGNC:39748
Rattus norvegicus	CXCL14	RGD	RGD:1307406
Felis catus	CXCL14	VGNC	VGNC:61297
Macaca mulatta	CXCL14	VGNC	VGNC:71394
Bos taurus	CXCL14	VGNC	VGNC:27850
Mus musculus	CXCL14	MGD	MGI:1888514
Others	CXCL14	NCBI

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