ENTPD4 - ectonucleoside triphosphate diphosphohydrolase 4 Gene

Homo sapiens

Also known as LAP70; LALP70; LYSAL1; UDPase; NTPDase-4

Gene ID: 9583 | Gene type: protein coding

About ENTPD4

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,429,162-23,457,647 (from NCBI)

This gene has 11 transcripts (splice variants), 212 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 16.0), appendix (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]

ENTPD4 Products(2)

mRNA	Protein	Name
NM_001128930.3	NP_001122402.1	ectonucleoside triphosphate diphosphohydrolase 4 isoform b
NM_004901.5	NP_004892.1	ectonucleoside triphosphate diphosphohydrolase 4 isoform a

ENTPD4 Protein Structure

GDA1_CD39

0
100
200
300
400
500
616 a.a.

Protein Preferred Names

Protein Names

ectonucleoside triphosphate diphosphohydrolase 4

Golgi UDPase

Related Diseases

Diseases

Alias

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04398	ENTPD4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENTPD4	VGNC	VGNC:56947
Rattus norvegicus	ENTPD4	RGD	RGD:1309511
Canis familiaris	ENTPD4	VGNC	VGNC:40383
Felis catus	ENTPD4	VGNC	VGNC:61881

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