2. Gene
  3. CD53 - CD53 molecule Gene

CD53 - CD53 molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MOX44; TSPAN25

Gene ID: 963 | Gene type: protein coding

About CD53

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,871,210-110,899,922 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 32 paralogues. Biased expression in lymph node (RPKM 181.8), appendix (RPKM 156.6) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

CD53 Products(3)

mRNA Protein Name
NM_000560.4 NP_000551.1 leukocyte surface antigen CD53 isoform 1
NM_001040033.2 NP_001035122.1 leukocyte surface antigen CD53 isoform 1
NM_001320638.2 NP_001307567.1 leukocyte surface antigen CD53 isoform 2

CD53 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (9 - 210)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

leukocyte surface antigen CD53

CD53 antigen

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02254 CD53 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CD53 VGNC VGNC:27039
Felis catus CD53 VGNC VGNC:60633
Canis familiaris CD53 VGNC VGNC:38964
Rattus norvegicus CD53 RGD RGD:2310
Macaca mulatta CD53 VGNC VGNC:70771
Mus musculus CD53 MGD MGI:88341
Macaca fascicularis CD53 NCBI
Others CD53 NCBI