2. Gene
  3. PPP6R2 - protein phosphatase 6 regulatory subunit 2 Gene

PPP6R2 - protein phosphatase 6 regulatory subunit 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP6R2; SAPS2; SAP190; KIAA0685

Gene ID: 9701 | Gene type: protein coding

About PPP6R2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,330,774-50,445,090 (from NCBI)

This gene has 9 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 24.1), brain (RPKM 12.1) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop Phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]

PPP6R2 Products(13)

mRNA Protein Name
NM_001242898.2 NP_001229827.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1
NM_001242899.2 NP_001229828.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2
NM_001242900.2 NP_001229829.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 4
NM_001351641.2 NP_001338570.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 5
NM_001351642.2 NP_001338571.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 6
NM_001351643.2 NP_001338572.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1
NM_001351644.2 NP_001338573.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 7
NM_001351645.2 NP_001338574.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3
NM_001351646.2 NP_001338575.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 8
NM_001351647.2 NP_001338576.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 9
NM_001351648.2 NP_001338577.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 10
NM_001365836.1 NP_001352765.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 11
NM_014678.5 NP_055493.2 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

PPP6R2 Protein Structure

SAPS

SAPS: SIT4 phosphatase-associated protein (129 - 360)

SAPS

SAPS: SIT4 phosphatase-associated protein (361 - 531)

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  • 966 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 6 regulatory subunit 2

SAPS domain family, member 2

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, Type 4b3

Charcot-Marie-Tooth Disease Type 4b3

CMT4B3

Charcot-Marie-Tooth Disease With Focally Folded Myelin

Charcot-Marie-Tooth Disease 4b3

Charcot-Marie-Tooth Neuropathy Type 4b3
Acute Cor Pulmonale
Acute Pulmonary Heart Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11035 PPP6R2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPP6R2 VGNC VGNC:33274
Macaca mulatta PPP6R2 VGNC VGNC:76288
Rattus norvegicus PPP6R2 RGD RGD:1563990
Mus musculus PPP6R2 MGD MGI:1918724
Felis catus PPP6R2 VGNC VGNC:64333
Canis familiaris PPP6R2 VGNC VGNC:44926