ARHGEF17 - Rho guanine nucleotide exchange factor 17 Gene

Homo sapiens

Also known as TEM4; RHOGEF17; P164RHOGEF; p164-RhoGEF

Gene ID: 9828 | Gene type: protein coding

About ARHGEF17

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,308,276-73,369,388 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 12.7), fat (RPKM 10.8) and 24 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within actin Cytoskeleton organization. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ARHGEF17 Products(1)

mRNA	Protein	Name
NM_014786.4	NP_055601.2	rho guanine nucleotide exchange factor 17

ARHGEF17 Protein Structure

RhoGEF

0
400
800
1200
1600
2063 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 17

164 kDa Rho-specific guanine-nucleotide exchange factor

Related Diseases

Diseases

Alias

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00952	ARHGEF17 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARHGEF17	VGNC	VGNC:59902
Mus musculus	ARHGEF17	MGD	MGI:2673002
Rattus norvegicus	ARHGEF17	RGD	RGD:1309890
Bos taurus	ARHGEF17	VGNC	VGNC:26109
Canis familiaris	ARHGEF17	VGNC	VGNC:38078
Macaca mulatta	ARHGEF17	VGNC	VGNC:69880

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