GOLGA5 - golgin A5 Gene

Homo sapiens

Also known as RFG5; GOLIM5; ret-II

Gene ID: 9950 | Gene type: protein coding

About GOLGA5

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,794,305-92,839,947 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 69 phenotypes. Ubiquitous expression in testis (RPKM 23.6), thyroid (RPKM 21.8) and 25 other tissues.

Summary

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the RET proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

GOLGA5 Products(1)

mRNA	Protein	Name
NM_005113.4	NP_005104.4	golgin subfamily A member 5

GOLGA5 Protein Structure

Golgin_A5

0
200
400
600
731 a.a.

Protein Preferred Names

Protein Names

golgin subfamily A member 5

RET-fused gene 5 protein

Related Diseases

Diseases

Alias

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Congenital Disorder Of Glycosylation, Type Iig

CDG2G	Congenital Disorder Of Glycosylation Type Iig
Cdg Iig	Cdgiig
Cdgii/Cog1 Cerebrocostomandibular-Like Syndrome	Carbohydrate Deficient Glycoprotein Syndrome Type Iig
Cdg-Iig	Congenital Disorder Of Glycosylation, Type 2g
Cog1-Cdg	Cdg Syndrome Type Iig
Congenital Disorder Of Glycosylation Type 2g	Congenital Disorder Of Glycosylation 2g
Cdg-Ii Caused By Cog1 Deficiency	Glycosylation, Congenital Disorder Of, Type Iig

Chlamydia

Chlamydial Infection	Chlamydia Trachomatis Infectious Disease
Chlamydial Disease	Chlamydia Infections

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05586	GOLGA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GOLGA5	VGNC	VGNC:41341
Macaca mulatta	GOLGA5	VGNC	VGNC:73108
Rattus norvegicus	GOLGA5	RGD	RGD:1308163
Felis catus	GOLGA5	VGNC	VGNC:62640
Bos taurus	GOLGA5	VGNC	VGNC:29486
Mus musculus	GOLGA5	MGD	MGI:1351475

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