H-Gly-Pro-Gly-NH2 

H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 III_B and HIV-2 ROD with EC₅₀ values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research^[1][2][3].

H-Gly-Pro-Gly-NH2 (5, 20 and 100 µM) shows antiviral activities in HUT78 cells infected with HIV-1 SF-2^[1].
H-Gly-Pro-Gly-NH2 (100 µM) destroys the capsid of HIV-1 virus particles in ACH-2 cells^[1].
Antiviral activity of H-Gly-Pro-Gly-NH2 against clinical HIV-1^[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

228.25

C₉H₁₆N₄O₃

141497-12-3

H-Gly-Pro-Gly-NH2

GPG-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Höglund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605.  [Content Brief]

  [2]. Andersson E, et al. No cross-resistance or selection of HIV-1 resistant mutants in vitro to the antiretroviral tripeptide glycyl-prolyl-glycine-amide[J]. Antiviral research, 2004, 61(2): 119-124.

  [3]. Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59.  [Content Brief]