2. Neuronal Signaling
  3. Beta-secretase Cholinesterase (ChE)
  4. hAChE-IN-7

hAChE-IN-7 (compound 5s) is a mixed inhibitor affecting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. hAChE-IN-7 displays the balanced inhibitory effect on hAChE (IC50=69.8 nM) and hBuChE (IC50=68.0 nM), and exhibits inhibitory activity against β-secretase-1 (BACE-1) (IC50=3.6 μM). hAChE-IN-7 has the potential for Alzheimer's disease (AD) research.

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hAChE-IN-7 Chemical Structure

hAChE-IN-7 Chemical Structure

CAS No. : 2978613-03-3

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hAChE-IN-7 Related Antibodies

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Description

hAChE-IN-7 (compound 5s) is a mixed inhibitor affecting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. hAChE-IN-7 displays the balanced inhibitory effect on hAChE (IC50=69.8 nM) and hBuChE (IC50=68.0 nM), and exhibits inhibitory activity against β-secretase-1 (BACE-1) (IC50=3.6 μM). hAChE-IN-7 has the potential for Alzheimer's disease (AD) research[1].

Molecular Weight

601.86

Formula

C38H55N3O3
CAS No.
SMILES

COC1=C(C=CC(CNC(CCCCCCC(C)C)=O)=C1)OCCCCCCCNC2=C3C=CC=CC3=NC4=C2CCCC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hAChE-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hAChE-IN-72978613-03-3Beta-secretaseCholinesterase (ChE)BACEβ-Secretasecatalytic active siteperipheral anionic sitePAS,? hAChEhBuChEβ-secretase-1BACE-1Alzheimer's diseaseADInhibitorinhibitorinhibit

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