2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. RAR/RXR Apoptosis
  4. HX630

HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research.

For research use only. We do not sell to patients.

HX630 Chemical Structure

HX630 Chemical Structure

CAS No. : 188844-52-2

Size Price Stock Quantity
5 mg USD 644 Get quote 2 weeks 1 week
10 mg USD 1030 Get quote 2 weeks 1 week
50 mg USD 3089 Get quote 2 weeks 1 week
100 mg   Get quote  
200 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

HX630 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research[1].

In Vitro

HX630 (0.1-10 μM, 96 h) can dose-dependently inhibit cell proliferation and induce apoptosis of AtT20 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HX630 Related Antibodies

Cell Viability Assay[1]

Cell Line: AtT20 cells
Concentration: 0.1, 1, 5, 10 μM
Incubation Time: 96 h
Result: Significantly inhibited AtT20 cell proliferation at 10 μM.
Decreased Pomc mRNA expression and ACTH secretion in a dose-dependent manner.
In Vivo

HX630 (5 mg/kg, intraperitoneal injection, 3 times a week for 3 weeks) can reduce tumor growth in BALB/c-nu mouse model infected with AtT20 cells[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c-nu mice (nu/nu) with AtT20 cells[1]
Dosage: 5 mg/kg
Administration: i.p., 3 times a week for 3 weeks
Result: Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different.
Molecular Weight

441.58

Formula

C28H27NO2S
CAS No.
SMILES

O=C(O)C1=CC=C(C(C2=C3)=NC4=CC=CC=C4SC2=CC5=C3C(C)(C)CCC5(C)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HX630 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HX630188844-52-2HX 630HX-630RAR/RXRApoptosisRetinoic acid receptorsRetinoid X receptorsretinoic acid X receptorapoptosisanti-tumorCushing's diseaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HX630
Cat. No.:
HY-108520
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.