2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. Ibiglustat succinate

Ibiglustat succinate  (Synonyms: Venglustat succinate; SAR402671 succinate; GZ402671 succinate)

Cat. No.: HY-16743B Purity: 99.92%
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Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

For research use only. We do not sell to patients.

Ibiglustat succinate Chemical Structure

Ibiglustat succinate Chemical Structure

CAS No. : 1629063-80-4

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Based on 2 publication(s) in Google Scholar

Other Forms of Ibiglustat succinate:

Ibiglustat succinate Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Ibiglustat succinate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease[1][2].

In Vitro

Ibiglustat (SAR402671) succinate (1 μM, 15 days; Fabry disease (FD) cells) is close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat succinate can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ibiglustat succinate Related Antibodies
Clinical Trial
Molecular Weight

507.57

Formula

C24H30FN3O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C.OC(CCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (492.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9702 mL 9.8509 mL 19.7017 mL
5 mM 0.3940 mL 1.9702 mL 3.9403 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9702 mL 9.8509 mL 19.7017 mL 49.2543 mL
5 mM 0.3940 mL 1.9702 mL 3.9403 mL 9.8509 mL
10 mM 0.1970 mL 0.9851 mL 1.9702 mL 4.9254 mL
15 mM 0.1313 mL 0.6567 mL 1.3134 mL 3.2836 mL
20 mM 0.0985 mL 0.4925 mL 0.9851 mL 2.4627 mL
25 mM 0.0788 mL 0.3940 mL 0.7881 mL 1.9702 mL
30 mM 0.0657 mL 0.3284 mL 0.6567 mL 1.6418 mL
40 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2314 mL
50 mM 0.0394 mL 0.1970 mL 0.3940 mL 0.9851 mL
60 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8209 mL
80 mM 0.0246 mL 0.1231 mL 0.2463 mL 0.6157 mL
100 mM 0.0197 mL 0.0985 mL 0.1970 mL 0.4925 mL
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Ibiglustat succinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ibiglustat1629063-80-4VenglustatSAR402671GZ402671SAR 402671SAR-402671GZ 402671GZ-402671Glucosylceramide Synthase (GCS)GBAmutationsoralGL-3 levelsFabry diseaseParkinson's diseaseInhibitorinhibitorinhibit

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