Iboxamycin 

Iboxamycin is a potent antibiotic candidate bearing a fused bicyclic amino acid residue. Iboxamycin is orally bioavailable, safe and effective in researching both Gram-positive and Gram-negative bacterial infections in mice^[1][2].

Iboxamycin is effective against ESKAPE pathogens including strains expressing Erm and Cfr ribosomal RNA methyltransferase enzymes, products of genes that confer resistance to all clinically relevant antibiotics targeting the large ribosomal subunit, namely macrolides, lincosamides, phenicols, oxazolidinones, pleuromutilins and streptogramins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

495.07

C₂₂H₃₉ClN₂O₆S

2640000-92-4

O=C([C@@H](NC1)[C@@](OCC2)([H])[C@@]1([H])C[C@@H]2CC(C)C)N[C@@H]([C@@]([C@@H]([C@@H]3O)O)([H])O[C@@H]([C@@H]3O)SC)[C@@H](Cl)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mason JD, et al. Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate. J Am Chem Soc. 2021;143(29):11019-11025.  [Content Brief]

  [2]. Mitcheltree MJ, et al. A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature. 2021;599(7885):507-512.  [Content Brief]