Indomethacin sodium (Synonyms: Indometacin sodium)

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Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research..

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Indomethacin sodium Chemical Structure

CAS No. : 7681-54-1

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Other In-stock Forms of Indomethacin sodium:

Other Forms of Indomethacin sodium:

Indomethacin In-stock
Indomethacin sodium hydrate In-stock

31 Publications Citing Use of MCE Indomethacin sodium

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Description

IC₅₀ & Targetsup>[1]

COX-1

18 nM (IC₅₀)

COX-2

26 nM (IC₅₀)

In Vitro

Indomethacin (Indometacin) sodium (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro^[2].
Indomethacin (Indometacin) sodium (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC₅₀=2μM)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
Concentration:	0, 20, 50, 100 and 150μM
Incubation Time:	24 hours
Result:	Inhibited cell viability at 20 mM, with 50% inhibition at 60 nM.

Cell Cycle Analysis^[2]

Cell Line:	3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
Concentration:	0, 30 and 80μM
Incubation Time:	24 hours
Result:	Decreased in the percentage of cells at the G2/M phase and increased in the percentage of cells at G1 phase.

In Vivo

Indomethacin (Indometacin) sodium (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia^[1].
Indomethacin (Indometacin) sodium (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	0.01-10 mg/kg
Administration:	Oral administration; for 3 hours
Result:	Inhibited the carrageenan-induced rat paw oedema (ED₅₀=2.0 mg/kg) and hyperalgesia (ED₅₀=1.5 mg/kg) in a dose-dependent manner.

Animal Model:	Male C57BL/6J mice^[2]
Dosage:	10 mg/mL
Administration:	Oral administration; daily, for 29 days
Result:	Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.

Clinical Trial

Molecular Weight

379.77

Formula

C₁₉H₁₅ClNNaO₄

CAS No.

7681-54-1

SMILES

O=C(O[Na])CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Riendeau D, et, al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [Content Brief]

[2]. Amici C, et, al. Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404. [Content Brief]

[3]. Eli Y, et, al. Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Biochem Pharmacol. 2001 Mar 1;61(5):565-71. [Content Brief]

Indomethacin sodium Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indomethacin7681-54-1IndometacinCOXAntibioticInfluenza VirusBacterialCyclooxygenaseanti-infectiveanticancerinflammationCOX-1COX-2Inhibitorinhibitorinhibit

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