Infigratinib-d₃ (Synonyms: BGJ-398-d₃; NVP-BGJ398-d₃)

Cat. No.: HY-13311S: FAQs
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Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC₅₀ values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

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Infigratinib-d<sub>3</sub> Chemical Structure

Infigratinib-d₃ Chemical Structure

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Other Forms of Infigratinib-d₃:

Infigratinib In-stock
Infigratinib phosphate In-stock

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Description	Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC₅₀ values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively^[1].
Molecular Weight	563.49
Formula	C₂₆H₂₈D₃Cl₂N₇O₃
SMILES	CCN1CCN(C2=CC=C(NC3=NC=NC(N(C([2H])([2H])[2H])C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)=C3)C=C2)CC1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T [Content Brief]

Infigratinib-d₃ Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Infigratinib-d₃BGJ-398-d₃ NVP-BGJ398-d₃FGFRFibroblast growth factor receptordeuterated analogcancerInhibitorinhibitorinhibit

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Infigratinib-d3 (Synonyms: BGJ-398-d3; NVP-BGJ398-d3)

Other Forms of Infigratinib-d3:

Infigratinib-d3 Related Antibodies

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•Related Proteins:

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Purity & Documentation

References

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Infigratinib-d3 Related Classifications