2. Epigenetics
  3. Epigenetic Reader Domain
  4. JQ1-TCO

JQ1-TCO is the double bond E configuration of JQ1-TCO (HY-148864A). JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo.

For research use only. We do not sell to patients.

JQ1-TCO Chemical Structure

JQ1-TCO Chemical Structure

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Other Forms of JQ1-TCO:

JQ1-TCO Related Antibodies

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Description

JQ1-TCO is the double bond E configuration of JQ1-TCO (HY-148864A). JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].

IC50 & Target[2]

BRD4

 

In Vitro

JQ1-TCO (10 μM; 18 h) doesn’t induces significant degradation of BRD4 in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JQ1-TCO Related Antibodies
Molecular Weight

609.18

Formula

C31H37ClN6O3S
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCCNC(OC4CC/C=C/CCC4)=O)=O)C5=NN=C(C)N25
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (164.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6416 mL 8.2078 mL 16.4155 mL
5 mM 0.3283 mL 1.6416 mL 3.2831 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6416 mL 8.2078 mL 16.4155 mL 41.0388 mL
5 mM 0.3283 mL 1.6416 mL 3.2831 mL 8.2078 mL
10 mM 0.1642 mL 0.8208 mL 1.6416 mL 4.1039 mL
15 mM 0.1094 mL 0.5472 mL 1.0944 mL 2.7359 mL
20 mM 0.0821 mL 0.4104 mL 0.8208 mL 2.0519 mL
25 mM 0.0657 mL 0.3283 mL 0.6566 mL 1.6416 mL
30 mM 0.0547 mL 0.2736 mL 0.5472 mL 1.3680 mL
40 mM 0.0410 mL 0.2052 mL 0.4104 mL 1.0260 mL
50 mM 0.0328 mL 0.1642 mL 0.3283 mL 0.8208 mL
60 mM 0.0274 mL 0.1368 mL 0.2736 mL 0.6840 mL
80 mM 0.0205 mL 0.1026 mL 0.2052 mL 0.5130 mL
100 mM 0.0164 mL 0.0821 mL 0.1642 mL 0.4104 mL
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JQ1-TCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JQ1-TCOEpigenetic Reader DomainInhibitorinhibitorinhibit

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HY-148864
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