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  3. Lin28-let-7 antagonist 1

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.

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Lin28-let-7 antagonist 1 Chemical Structure

Lin28-let-7 antagonist 1 Chemical Structure

CAS No. : 108825-65-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 94 In-stock
Solution
10 mM * 1 mL in DMSO USD 94 In-stock
Solid
5 mg USD 85 In-stock
10 mg USD 135 In-stock
25 mg USD 285 In-stock
50 mg USD 460 In-stock
100 mg USD 735 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells[1].

Molecular Weight

281.31

Formula

C15H15N5O

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(C(C)=O)C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (177.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5548 mL 17.7740 mL 35.5480 mL
5 mM 0.7110 mL 3.5548 mL 7.1096 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5548 mL 17.7740 mL 35.5480 mL 88.8699 mL
5 mM 0.7110 mL 3.5548 mL 7.1096 mL 17.7740 mL
10 mM 0.3555 mL 1.7774 mL 3.5548 mL 8.8870 mL
15 mM 0.2370 mL 1.1849 mL 2.3699 mL 5.9247 mL
20 mM 0.1777 mL 0.8887 mL 1.7774 mL 4.4435 mL
25 mM 0.1422 mL 0.7110 mL 1.4219 mL 3.5548 mL
30 mM 0.1185 mL 0.5925 mL 1.1849 mL 2.9623 mL
40 mM 0.0889 mL 0.4443 mL 0.8887 mL 2.2217 mL
50 mM 0.0711 mL 0.3555 mL 0.7110 mL 1.7774 mL
60 mM 0.0592 mL 0.2962 mL 0.5925 mL 1.4812 mL
80 mM 0.0444 mL 0.2222 mL 0.4443 mL 1.1109 mL
100 mM 0.0355 mL 0.1777 mL 0.3555 mL 0.8887 mL
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Lin28-let-7 antagonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lin28-let-7 antagonist 1
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HY-112659
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