2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M40 TFA

M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas.

For research use only. We do not sell to patients.

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M40 TFA Chemical Structure

M40 TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of M40 TFA:

  • M40 Get quote

M40 TFA Related Antibodies

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Description

M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].

In Vivo

M40 TFA (0.1-1 nmol, intracisternal injection, single dose) blocks selectively the central cardiovascular responses induced by galanin-(1–15) in Sprague-Dawley rats models, according to the recognization of galanin receptor in N-terminus[1].
M40 TFA (2-8 nmol, intraventricular or intrahippocampal, single dose) exhibits antagonist efficacy against galanin on memory tasks in sprague-dawley rats models, exhibits potency in alleviating the cognitive deficits associated with Alzheimer's disease[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1]
Dosage: 0.1-1 nmol
Administration: Intracisternal injection, single dose
Result: Blocked the feeding effects of galanin in the hypothalamus and amygdala.
Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29).
Animal Model: Memory impairment induced by galanin in rats model[2]
Dosage: 2-8 nmol
Administration: intraventricular or intrahippocampal, single dose
Result: Blocked the impairment in choice accuracy.
Molecular Weight

1980.31 (free base)

Formula

C95H146N22O24.xC2HF3O2
Appearance

Solid

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence Shortening

GWTLNSAGYLLGPPPALALA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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M40 TFA Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M40M 40M-40Neuropeptide Y ReceptorNPY receptorSprague-Dawley ratsmemory impairmentalzheimer’s diseaseInhibitorinhibitorinhibit

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