2. Academic Validation
  3. In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae)

In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae)

  • J Ethnopharmacol. 2000 Jan;69(1):27-33. doi: 10.1016/s0378-8741(99)00117-8.
J Bickii 1,  N Njifutie,  J A Foyere,  L K Basco,  P Ringwald
Affiliations

Affiliation

  • 1 Institut de Recherche pour le Développement (ORSTOM) and Laboratoire de Recherche sur le Paludisme, Laboratoire Associé Francophone 302, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale, Yaoundé, Cameroon.
PMID: 10661881 DOI: 10.1016/s0378-8741(99)00117-8
Abstract

The crude extract from the bark and seeds of Khaya grandifoliola was active in vitro against Plasmodium falciparum with an IC50 value of 13.23 microg/ml. The extract was purified to obtain seven limonoids--methylangolensate (1), 6-methylhydroxyangolensate (2), gedunin (3), 7-deacetylkhivorin (5), 1-deacetylkhivorin (6), swietenolide (7), 6-acetylswietenolide (8)--and one flavonoid, catechin (4). Five limonoids (1, 3, 5, 6, 8) were active with IC50 values between 1.25 and 9.63 microg/ml. Catechin was practically devoid of activity. The most active limonoid, gedunin, exhibited an additive effect when combined with chloroquine.

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