2. Academic Validation
  3. Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative

Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative

  • Bioorg Med Chem Lett. 2002 Jan 21;12(2):265-6. doi: 10.1016/s0960-894x(01)00728-4.
David Egron 1,  Christian Périgaud,  Gilles Gosselin,  Anne-Marie Aubertin,  Hiroyuki Gatanaga,  Hiroaki Mitsuya,  Jiri Zemlicka,  Jean-Louis Imbach
Affiliations

Affiliation

  • 1 UMR CNRS 5625, Université Montpellier II, cc 008, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
PMID: 11755368 DOI: 10.1016/s0960-894x(01)00728-4
Abstract

The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4'-hydroxy-1',2'-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.

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