2. Academic Validation
  3. Cytotoxic lignans from Larrea tridentata

Cytotoxic lignans from Larrea tridentata

  • Phytochemistry. 2005 Apr;66(7):811-5. doi: 10.1016/j.phytochem.2005.02.007.
Joshua D Lambert 1,  Shengmin Sang,  Ann Dougherty,  Colby G Caldwell,  Ross O Meyers,  Robert T Dorr,  Barbara N Timmermann
Affiliations

Affiliation

  • 1 Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA. [email protected]
PMID: 15797607 DOI: 10.1016/j.phytochem.2005.02.007
Abstract

Six Lignans, including the cyclolignan 3,4'-dihydroxy-3',4'-dimethoxy-6,7'-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone, (S)-4',5-dihydroxy-7-methoxyflavanone, was isolated for the first time from L. tridentata or any member of the family Zygophyllaceae. All of the compounds were assessed for their growth inhibitory activity against human breast Cancer, human colon Cancer and human melanoma cell lines. The Lignans had IC50 values of 5-60 microM with the linear butane-type Lignans being the most potent, and it was found that colon Cancer cells were the least sensitive cell type tested. The relative potency of linear butane type Lignans against human breast Cancer appears to correlate positively with the number of O-methyl groups present on the molecule.

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