2. Academic Validation
  3. Alkaloids from Gelsemium elegans

Alkaloids from Gelsemium elegans

  • J Nat Prod. 2006 Sep;69(9):1347-50. doi: 10.1021/np060156y.
You-Kai Xu 1,  Sheng-Ping Yang,  Shang-Gao Liao,  Hua Zhang,  Li-Ping Lin,  Jian Ding,  Jian-Min Yue
Affiliations

Affiliation

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
PMID: 16989532 DOI: 10.1021/np060156y
Abstract

Three new Alkaloids, gelsebanine (1), 14alpha-hydroxyelegansamine (2), and 14alpha-hydroxygelsamydine (3), and a new extraction artifact , gelsebamine (4), together with 12 known Alkaloids, were isolated from the stems and leaves of Gelsemium elegans. The structures of 1-4 were determined by spectroscopic methods, especially 2D NMR techniques. Compounds 1-4 were evaluated for cytotoxic activity against four tumor cell lines, and gelsebamine (4) selectively inhibited the A-549 human lung adenocarcinoma cell line.

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