2. Academic Validation
  3. Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents

Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents

  • Bioorg Med Chem Lett. 2007 Dec 15;17(24):6895-8. doi: 10.1016/j.bmcl.2007.09.096.
Maria Cristina Silva Lourenço 1,  Felipe Rodrigues Vicente,  Maria das Graças Muller de Oliveira Henriques,  André Luis Peixoto Candéa,  Raoni Schroeder Borges Gonçalves,  Thais Cristina M Nogueira,  Marcelle de Lima Ferreira,  Marcus Vinícius Nora de Souza
Affiliations

Affiliation

  • 1 Instituto de Pesquisas Clínica Evandro Chagas-IPEC, Av. Brasil, 4365 Manguinhos Rio de Janeiro, RJ, Brazil.
PMID: 17967538 DOI: 10.1016/j.bmcl.2007.09.096
Abstract

The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro Antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 microg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis.

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