2. Academic Validation
  3. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers

Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers

  • Phytomedicine. 2013 Apr 15;20(6):506-11. doi: 10.1016/j.phymed.2013.01.002.
Vaibhav Mishra 1,  Manali Agrawal,  Samuel Adetunji Onasanwo,  Gaurav Madhur,  Preeti Rastogi,  Haushila Prasad Pandey,  Gautam Palit,  Tadigoppula Narender
Affiliations

Affiliation

  • 1 Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, UP, India.
PMID: 23462212 DOI: 10.1016/j.phymed.2013.01.002
Abstract

In continuation of our drug discovery program on Indian medicinal Plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of chebulinic acid was observed against CRU (62.9%), AS (55.3%), AL (80.67%) and PL (66.63%) induced ulcer models. The reference drug omeprazole (10 mg/kg, p.o.) showed 77.73% protection against CRU, 58.30% against AS and 70.80% against PL model. Sucralfate, another reference drug (500 mg/kg, p.o.) showed 65.67% protection in AL induced ulcer model. Chebulinic acid significantly reduced free acidity (48.82%), total acidity (38.29%) and upregulated Mucin secretion by 59.75% respectively. Further, chebulinic acid significantly inhibited H(+) K(+)-ATPase activity in vitro with IC50 of 65.01 μg/ml as compared to the IC50 value of omeprazole (30.24 μg/ml) confirming its anti-secretory activity.

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