2. Academic Validation
  3. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases

ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases

Barbara Calamini 1,  Maria Catarina Silva 1 2,  Franck Madoux 3,  Darren M. Hutt 4,  Shilpi Khanna 5,  Monica A. Chalfant 4,  Christophe Allais 6,  Souad Ouizem 6,  Sanjay A. Saldanha 3,  Jill Ferguson 3,  Becky A. Mercer 3,  Cameron Michael 7,  Bradley D. Tait 5,  Dan Garza 5,  William E. Balch 4,  William R. Roush 6,  Richard I. Morimoto 1,  Peter Hodder 3
Affiliations

Affiliations

  • 1 Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, USA
  • 2 Faculty of Sciences, Centre for Biodiversity, Functional and Integrative Genomics; (BioFIG), University of Lisboa, Lisboa, Portugal
  • 3 Scripps Research Institute Molecular Screening Center, Lead Identification Division, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, USA
  • 4 Department of Cell Biology and Chemical Physiology, Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA, USA
  • 5 Proteostasis Therapeutics Inc., Cambridge, MA, USA
  • 6 Department of Chemistry, The Scripps Research Institute, Scripps Florida
  • 7 Discovery Biology, Drug Metabolism and Pharmacokinetics, The Scripps Research Institute Florida
PMID: 23833797
Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-18669
    98.71%, Hsp70 Activator
    HSP