2. Academic Validation
  3. Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy

Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy

  • Nat Prod Res. 2017 Jun;31(11):1277-1285. doi: 10.1080/14786419.2016.1242000.
Houari Benamar 1 2,  Lamberto Tomassini 3,  Alessandro Venditti 3,  Abderrazak Marouf 1 4,  Malika Bennaceur 1 5,  Mauro Serafini 3,  Marcello Nicoletti 3
Affiliations

Affiliations

  • 1 a Faculty of Natural Sciences and Life, Laboratory of Biochemistry and Natural Products, Department of Biology , University of Oran 1 Ahmed Benbella , Oran , Algeria.
  • 2 b Faculty of Natural Sciences and Life, Department of Biology , University of Mostaganem Abdelhamid Ibn Badis , Mostaganem , Algeria.
  • 3 c Department of Environmental Biology , University "Sapienza" , Rome , Italy.
  • 4 d Department of Natural Sciences and Life , Institute of Science and Technology, Ctr Univ Naama , Naama , Algeria.
  • 5 e Faculty of Biological Sciences, Laboratory of Research in Arid Areas , University of Science and Technology Houari Boumediene , Algiers , Algeria.
PMID: 27748125 DOI: 10.1080/14786419.2016.1242000
Abstract

Four pyrrolizidine Alkaloids, namely 7-O-angeloyllycopsamine N-oxide 1, echimidine N-oxide 2, echimidine 3 and 7-O-angeloylretronecine 4, were isolated for the first time from the whole plant ethanolic extract of Echium confusum Coincy, through bioassay-guided approach. Their structures were determined by spectroscopic means. All the isolates compounds showed moderate activities in inhibiting AChE, with IC50 0.276-0.769.

Keywords

7-O-angeloyllycopsamine N-oxide; Boraginaceae; Echium confusum; anti-AChE activity; pyrrolizidine alkaloids.

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