2. Academic Validation
  3. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

  • Oncotarget. 2017 Jun 13;8(24):38554-38567. doi: 10.18632/oncotarget.16170.
Kyeongeun Song 1 2,  Li Xu 1,  Wei Zhang 1,  Yun Cai 1,  Bian Jang 1 2 3 4,  Junghwan Oh 2 3 4,  Jun-O Jin 1
Affiliations

Affiliations

  • 1 Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, 201508, China.
  • 2 Marine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513, Korea.
  • 3 Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, 48513, Korea.
  • 4 Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Pukyong National University, Busan, 48513, Korea.
PMID: 28423736 DOI: 10.18632/oncotarget.16170
Abstract

This research evaluates the effects of laminarin on the maturation of dendritic cells and on the in vivo activation of anti-cancer immunity. In vivo treatment of C56BL/6 mice with laminarin increased the expression levels of co-stimulatory molecules and the production of pro-inflammatory cytokines in spleen dendritic cells. Laminarin enhanced ovalbumin antigen presentation in spleen dendritic cells and promoted the proliferation of OT-I and OT-II T cells. Laminarin also induced the maturation of dendritic cells in tumor-draining lymph nodes and protected interferon-γ and tumor necrosis factor-α and proliferation of OT-I and OT-II T cells in tumors. The combination treatment of laminarin and ovalbumin inhibited B16-ovallbumin melanoma tumor growth and its liver metastasis by antigen-specific immune activation, including cytotoxic T lymphocyte activation and interferon-γ production. Thus, these data demonstrated the potential of laminarin as a new and useful immune stimulatory molecule for use in Cancer Immunotherapy.

Keywords

adjuvant; anti-cancer; cytotoxic lymphocyte activation; dendritic cell maturation; laminarin.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-119109
    ≥98.0%, Immunotherapy Agent