2. Academic Validation
  3. Triterpenoids and sterols from the grains of Echinochloa utilis Ohwi & Yabuno and their cytotoxic activity

Triterpenoids and sterols from the grains of Echinochloa utilis Ohwi & Yabuno and their cytotoxic activity

  • Biomed Pharmacother. 2017 Sep;93:202-207. doi: 10.1016/j.biopha.2017.06.042.
Thi Trang Nguyen 1,  Duc Hung Nguyen 2,  Bing Tian Zhao 3,  Duc Dat Le 3,  Byung Sun Min 3,  Young Ho Kim 4,  Mi Hee Woo 5
Affiliations

Affiliations

  • 1 College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea; Buon Ma Thuot University, Buon Ma Thuot City, Dak Lak Province 630000, Viet Nam.
  • 2 College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea; Phutho College of Medicine and Pharmacy, Viettri City, Phutho Province 290000, Viet Nam.
  • 3 College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea.
  • 4 Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 39061, Republic of Korea.
  • 5 College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea. Electronic address: [email protected].
PMID: 28641162 DOI: 10.1016/j.biopha.2017.06.042
Abstract

Two new tetracyclic triterpenoids, echinochlorins C (1) and D (2), and sawamilletin (3) with new spectroscopic data were isolated from Echinochloa utilis Ohwi & Yabuno grains, along with one known triterpenoid (4) and eight sterols (5-12). Their structures were elucidated by spectroscopic data analyses (IR, UV, MS, and NMR). These compounds were tested in vitro cytotoxic activities against the human tumor-cell lines (HeLa, HL-60, and MCF-7). Compounds 6 and 8 displayed potential cytotoxic activity against HeLa, with IC50 values of 3.1±0.9 and 3.2±0.8μM, respectively. This finding indicated that tetracyclic triterpenoids isolated from E. utilis may have potential beneficial effects for the treatment of Cancer.

Keywords

Cytotoxic activity; Echinochloa utilis; Echinochlorins C and D; Sawamilletin.

Figures
Products