2. Academic Validation
  3. Two new monoterpenoid indole alkaloids from Alstonia rostrata

Two new monoterpenoid indole alkaloids from Alstonia rostrata

  • Nat Prod Res. 2018 Apr;32(7):844-848. doi: 10.1080/14786419.2017.1360886.
Yu-Xi Yuan 1 2,  Feng Guo 2,  Hong-Ping He 1,  Yu Zhang 1 2,  Xiao-Jiang Hao 1 2
Affiliations

Affiliations

  • 1 a Yunnan University of Traditional Chinese Medicine , Kunming , China.
  • 2 b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
PMID: 28768429 DOI: 10.1080/14786419.2017.1360886
Abstract

Two new Indole Alkaloids, winphyllines A (1) and B (4), along with four known Alkaloids, Nb-demethylechitamine (2), 17-O-acetylnorechitamine (3), 12-methoxyechitamidine (5), and N(4)-demethylastogustine (6), were isolated from the methanol extract of the twigs of Alstonia rostrata. The structures of 1 and 4 were elucidated by means of HRMS and NMR spectroscopic methods. The in vitro cytotoxic activity of the isolated Alkaloids against several human Cancer cell lines was evaluated.

Keywords

Alstonia rostrata; Apocynaceae; monoterpene indole alkaloid.

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