2. Academic Validation
  3. Neuraminidase Inhibitory Activity and Constituent Characterization of Fagopyrum dibotrys

Neuraminidase Inhibitory Activity and Constituent Characterization of Fagopyrum dibotrys

  • Molecules. 2017 Nov 18;22(11):1998. doi: 10.3390/molecules22111998.
Xiang Zhang 1,  Yu Cao 2,  Jinhua Li 3,  Ailin Liu 4,  Haibo Liu 5,  Linfang Huang 6
Affiliations

Affiliations

  • 1 Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China. [email protected].
  • 2 Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China. [email protected].
  • 3 Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China. [email protected].
  • 4 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. [email protected].
  • 5 Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China. [email protected].
  • 6 Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China. [email protected].
PMID: 29156573 DOI: 10.3390/molecules22111998
Abstract

This study aimed to identify a new biological activity of the widely distributed species Fagopyrum dibotrys. Four F. dibotrys extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identified using UHPLC-Q-Exactive Orbitrap HRMS in the EA extract, which had the best NA inhibitory effects. We used the docking data for supporting compounds' anti-neuraminidase activity. Among them, five compounds including one flavonoid, three organic acids, and one glucoside were discovered for the first time in F. dibotrys. Docking studies and NA activity assay revealed the remarkable NA inhibitory activity of eight components in EA extract, especially rutin, hesperidin, procyanidin B₂, and quercitrin. Therefore, F. dibotrys could be used to develop anti-influenza drugs.

Keywords

Fagopyrum dibotrys; NA inhibitory activity; UHPLC-Q-Exactive; chemical constituents; molecular docking.

Figures
Products