2. Academic Validation
  3. Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors

Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors

  • Biochem Biophys Res Commun. 2019 Apr 2;511(2):468-475. doi: 10.1016/j.bbrc.2019.02.085.
Wentao Fan 1,  Xiaona Gao 1,  Chenchen Ding 1,  Yanan Lv 1,  Tongtong Shen 1,  Guangpeng Ma 2,  Liping Yan 3,  Suquan Song 4
Affiliations

Affiliations

  • 1 College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China.
  • 2 College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China.
  • 3 College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China.
  • 4 College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China. Electronic address: [email protected].
PMID: 30797557 DOI: 10.1016/j.bbrc.2019.02.085
Abstract

Increasing evidence indicates that the NOD-like receptors (NLRs) family may act as critical back-up defenses and provide synergistic responses when confronted with persistent danger. However, the precise regulatory mechanism of NLRs and the contribution of NLRs to Cancer are still unknown. In our previous study, we found that estrogen receptors (ERs) have a close connection with NLRs in the inflammatory response. Here, ERs are first identified as NLRs transcription regulation factors, both regulate NLRs expression and promote inflammasome co-localization. Furthermore, we identified that NLRP3 was differentially expressed in colon normal and Cancer cells, selective ERα Antagonist could significantly decrease pro-inflammatory cytokines expression, suppress proliferation and promote Apoptosis by inhibited NLRP3 expression and inflammasome activity. In short, the research demonstrates that ERs participate in the NLR-associated signaling pathway in Cancer by directly regulating NLRs. Our results provide novel insight into ERs as therapeutic targets in NLR-related inflammation and Cancer.

Keywords

Cancer; Estrogen receptor; Inflammasome; Inflammation; NOD-like receptors; Transcription factors.

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