2. Academic Validation
  3. Bioactive glycosides from Salacia cochinchinensis

Bioactive glycosides from Salacia cochinchinensis

  • Carbohydr Res. 2019 Oct 1:484:107777. doi: 10.1016/j.carres.2019.107777.
Hui-Mei You 1,  Jia-Wen Zhao 1,  Yu-Xing Jing 1,  Juan-Rong Zhang 1,  Wei Wang 1,  Yun-Tao Jiang 1,  Ai-Xue Zuo 2,  Jun-Ting Fan 3,  Li-Zhu Zhang 1,  Min Zhou 1,  Zhi-Yong Jiang 4
Affiliations

Affiliations

  • 1 Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Chenggong New District, Kunming, Yunnan, 650500, China.
  • 2 Yunnan University of Traditional Chinese Medicine, Chenggong New District, Kunming, Yunnan, 650500, China.
  • 3 Department of Pharmceutical Analysis, School of Pharmcy, Nanjing Medical University, Nanjing, 211166, China.
  • 4 Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Chenggong New District, Kunming, Yunnan, 650500, China. Electronic address: [email protected].
PMID: 31446303 DOI: 10.1016/j.carres.2019.107777
Abstract

Four new triterpene glycosides, named salaciacochinosides A-D (1-4) were isolated from the 90% ethanol extract of Salacia cochinchinensis, together with five known compounds 2α,3β,23-trihydroxyurs-12,18-dien-28-oic acid 28-O-β-d-glucopyranoside (5), racemiside (6), alangiplatanoside (7), acantrifoside E (8), and syringin (9). The structures of the four new triterpenoids were characterized by chemical methods and MS, IR, 1D and 2D NMR spectral analyses. The α-glucosidase inhibitory activities of the nine compounds were assessed, compounds 6 and 7 showed remarkable α-glucosidase inhibitory activities, with IC50 values of 0.44 and 0.75 μM, respectively. Compounds 1-5 exhibited moderate α-glucosidase inhibitory activities, and compounds 8 and 9 showed none α-glucosidase inhibitory activity in our current experiments.

Keywords

Salacia cochinchinensis; Salaciacochinosides A-D; Triterpene glycosides; α-glucosidase.

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