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  3. Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment

Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment

  • FEBS Lett. 2022 Feb;596(4):449-464. doi: 10.1002/1873-3468.14249.
Chengyu Wang 1 2,  Tong Zhu 3,  Zhangxiang Zhao 4,  Bo Chen 1,  Tingting Chen 1,  Qi Dong 1,  Mingyue Liu 1,  Shuping Zhuang 1,  Fan Yang 1,  Yaoyao Liu 1,  Min Yang 5,  Yunyan Gu 1,  Haihai Liang 4
Affiliations

Affiliations

  • 1 Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, China.
  • 2 Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, China.
  • 3 Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, China.
  • 4 The Sino-Russian Medical Research Center of Jinan University, The Institute of Chronic Disease of Jinan University, The First Affiliated Hospital of Jinan University, Guangzhou, China.
  • 5 Guangdong Cardiovascular Institute, Guangdong Province People's Hospital, Guangzhou, China.
PMID: 34855209 DOI: 10.1002/1873-3468.14249
Abstract

The Hippo signaling pathway is critical for carcinogenesis. However, the roles of the Hippo signaling pathway in the tumor immune microenvironment have been rarely investigated. This study systematically analyzed the relationship between the Hippo signaling pathway and immune cell infiltration across 32 Cancer types. Both bioinformatics analyses and biological experiments revealed that the downstream effector of Hippo signaling YAP1 might inhibit CD8+ T cell infiltration by upregulating the expression of the transcription factor CREB1 in uterine corpus endometrial carcinoma. In addition, esophageal carcinoma (ESCA) patients were classified into three subtypes based on the Hippo-immune gene panel. The subtypes of ESCA had distinct characteristics in immune cell infiltration, immune pathways, and prognosis. Thus, this study also reveals a new classification of the immune subtypes with prognostic characteristics in ESCA.

Keywords

Hippo signaling pathway; cancer; immune; multi-omics.

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  • Cat. No.
    Product Name
    Description
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  • HY-125269
    98.97%, YAP-TEAD Inhibitor
    YAP