2. Academic Validation
  3. New polychlorinated bibenzyls from Rhododendron minutiflorum

New polychlorinated bibenzyls from Rhododendron minutiflorum

  • Nat Prod Bioprospect. 2023 Jan 9;13(1):2. doi: 10.1007/s13659-022-00364-x.
Yang-Li Zhu # 1,  Li Deng # 1,  Yu Tang 1,  Xian-Zhe Fan 1,  Yang Han 2,  Mei Pan 3,  Li-Jun Zhang 4,  Hai-Bing Liao 5
Affiliations

Affiliations

  • 1 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, People's Republic of China.
  • 2 Guangxi Key Laboratory of Citrus Biology, Guangxi Academy of Specialty Crops, Guilin, 541004, People's Republic of China.
  • 3 Guilin Pharma Company, Guilin, 541007, People's Republic of China.
  • 4 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, People's Republic of China. [email protected].
  • 5 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, People's Republic of China. [email protected].
  • # Contributed equally.
PMID: 36617588 DOI: 10.1007/s13659-022-00364-x
Abstract

Five new polychlorinated bibenzyls (1-5) along with 3 known compounds (6-8) were isolated from the stems and leaves of Rhododendron minutiflorum. The chemical structures of all the isolates were determined by spectroscopic methods, and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses. Compounds 1-5 were halogenated compounds which bear three to five chlorine atoms in their chemical structures. Biologically, compounds 2, 5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid (Diaphorina citri) with LD50 values 27.15, 17.02 and 16.20 mg/L, respectively. These values were comparable to the positive control matrine (LD50 = 11.86 mg/L), which were calculated using observations on day 6. Meanwhile, compound 4 had α-glucosidase inhibitory activity with IC50 value of 17.87 ± 0.74 μM.

Keywords

Acarbose; Diaphorina citri; Insecticidal activity; Matrine; Polychlorinated bibenzyls; Rhododendron minutiflorum; α-Glucosidase inhibitory activity.

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