2. Academic Validation
  3. Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

  • Front Microbiol. 2023 Jan 10;13:1067725. doi: 10.3389/fmicb.2022.1067725.
Jicheng Han 1 2,  Xiangyu Zhu 1 3,  Zihan Gao 1 2,  Yan Xiao 1 2,  Jinxin Zhang 1 2,  Peng Wang 1 3,  Jinbo Fang 2,  Yiquan Li 2,  Yilong Zhu 2,  Yue Li 1 2,  Ningyi Jin 1 2,  Huijun Lu 1,  Dazhuan Lin 4,  Wenshen Liu 1
Affiliations

Affiliations

  • 1 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
  • 2 Academician Workstation, Changchun University of Chinese Medicine, Changchun, China.
  • 3 College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
  • 4 College of Pharmaceuticals and Food, Changchun Medical College, Changchun, China.
PMID: 36704555 DOI: 10.3389/fmicb.2022.1067725
Abstract

Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential Antiviral properties. This study shows that AA not only possesses anti-influenza B virus Infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus Infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza Infection.

Keywords

Atractyloside A; antiviral drugs; influenza B virus (IBV); influenza virus; macrophage polarization.

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