2. Academic Validation
  3. Hydrophobicity-Adaptive Polymers Trigger Fission of Tumor-Cell-Derived Microparticles for Enhanced Anticancer Drug Delivery

Hydrophobicity-Adaptive Polymers Trigger Fission of Tumor-Cell-Derived Microparticles for Enhanced Anticancer Drug Delivery

  • Adv Mater. 2023 Sep 27:e2211980. doi: 10.1002/adma.202211980.
Haojie Liu 1,  Shiyi Xu 1,  Tuying Yong 1 2 3 4 5,  Zhaohan Wei 1,  Nana Bie 1,  Xiaoqiong Zhang 1,  Xin Li 1,  Jianye Li 1,  Shiyu Li 1,  Sheng Wang 2,  Yanbing Zhao 1 2 3 4 5,  Xiangliang Yang 1 2 3 4 5,  Lu Gan 1 2 3 4 5
Affiliations

Affiliations

  • 1 National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • 2 Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • 3 Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • 4 Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • 5 Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan, 430074, China.
PMID: 37755231 DOI: 10.1002/adma.202211980
Abstract

Tumor-cell-derived microparticles (MPs) can function as Anticancer drug-delivery carriers. However, short blood circulation time, large-size-induced insufficient tumor accumulation and penetration into tumor parenchyma, as well as limited cellular internalization by tumor cells and Cancer Stem Cells (CSCs), and difficult intracellular drug release restrict the Anticancer activity of tumor-cell-derived MP-based drug-delivery systems. In this work, hydrophobicity-adaptive Polymers based on poly(N-isopropylacrylamide) are anchored to tumor-cell-derived MPs for enhanced delivery of the Anticancer drug doxorubicin (DOX). The Polymers are hydrophilic in blood to prolong the circulation time of DOX-loaded MPs (DOX@MPs), while rapidly switching to hydrophobic at the tumor acidic microenvironment. The hydrophobicity of Polymers drives the fission of tumor-cell-derived MPs to form small vesicles, facilitating tumor accumulation, deep tumor penetration, and efficient internalization of DOX@MPs into tumor cells and CSCs. Subsequently, the hydrophobicity of Polymers in acidic lysosomes further promotes DOX release to nuclei for strong cytotoxicity against tumor cells and CSCs. The work provides a facile and simple strategy for improved Anticancer drug delivery of tumor-cell-derived MPs.

Keywords

cancer chemotherapy; fission; hydrophobicity-adaptive polymers; in vivo transport processing; tumor-cell-derived microparticles.

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