2. Academic Validation
  3. Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis

Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis

  • Bioact Mater. 2023 Oct 7:32:164-176. doi: 10.1016/j.bioactmat.2023.09.020.
Haichao Yu 1 2,  Zelong Song 1 2,  Jie Yu 3,  Boyuan Ren 4,  Yuan Dong 2,  Yonggang You 2,  Zhen Zhang 2,  Chengqi Jia 5,  Yunpeng Zhao 6,  Xuhui Zhou 7,  Haifeng Sun 8,  Xuesong Zhang 2 1
Affiliations

Affiliations

  • 1 School of Medicine, Nankai University, Tianjin 300071, China.
  • 2 Department of Orthopaedics, The Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
  • 3 Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • 4 Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • 5 Department of Orthopedics, Beijing Jishuitan Hospital, Beijing 100035, China.
  • 6 Department of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, 250012, China.
  • 7 Department of Orthopaedics, Changzheng Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200003, China.
  • 8 School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, 271016, China.
PMID: 37822916 DOI: 10.1016/j.bioactmat.2023.09.020
Abstract

Osteoarthritis (OA) has emerged as a significant health concern among the elderly population, with increasing attention paid to ferroptosis-induced OA in recent years. However, the prolonged use of nonsteroidal anti-inflammatory drugs or corticosteroids can lead to a series of side effects and limited therapeutic efficacy. This study aimed to employ the Mannich condensation reaction between epigallocatechin-3-gallate (EGCG) and selenomethionine (SeMet) to efficiently synthesize polyphenol-based nanodrugs in aqueous media for treating OA. Molecular Biology experiments demonstrated that EGCG-based nanodrugs (ES NDs) could effectively reduce Glutathione Peroxidase 4 (GPX4) inactivation, abnormal Fe2+ accumulation, and lipid peroxidation induced by oxidative stress, which ameliorated the metabolic disorder of chondrocytes and other multiple pathological processes triggered by Ferroptosis. Moreover, imaging and histopathological analysis of the destabilization of the medial meniscus model in mice confirmed that ES NDs exhibiting significant therapeutic effects in relieving OA. The intra-articular delivery of ES NDs represents a promising approach for treating OA and other joint inflammatory diseases.

Keywords

Antioxidants; Ferroptosis; Nanodrug; Natural product; Osteoarthritis.

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