2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Mogroside V

Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research.

For research use only. We do not sell to patients.

Mogroside V Chemical Structure

Mogroside V Chemical Structure

CAS No. : 88901-36-4

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Based on 1 publication(s) in Google Scholar

Mogroside V Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research[1][3].

In Vitro

Mogroside V (20 μM, 40 h) reducs the ROS levels in in vitro maturation (IVM) oocytes[1].
Mogroside V (20 μM, 40 h) can enhance mitochondrial function in oocytes[1].
Mogroside V (1-250 μM, 24 h) promots apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells) and may be mediated through regulating the STAT3 signaling pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mogroside V Related Antibodies

Immunofluorescence[1]

Cell Line: IVM oocytes
Concentration: 20 μM
Incubation Time: 40 h
Result: Increased the fluorescence intensity compared to control group.
Increased the red/green fluorescence intensity ratio compared to control group.

Real Time qPCR[1]

Cell Line: IVM oocytes
Concentration: 20 μM
Incubation Time: 40 h
Result: Increased the relative mRNA expression of SOD, CAT, PGC-1α and TFAM than in control group.

Cell Viability Assay[3]

Cell Line: PANC-1 cells
Concentration: 1-250 μM
Incubation Time: 24 h
Result: Increased the percentage of TUNEL-positive cells ranging from 2.91% to 92.25%.

Apoptosis Analysis[3]

Cell Line: PANC-1 cells
Concentration: 1-250 μM
Incubation Time: 24 h
Result: Induced apoptosis in PANC-1 cells in a concentration- and time-dependent manner

Western Blot Analysis[3]

Cell Line: PANC-1 cells
Concentration: 0-250 μM
Incubation Time: 24 h
Result: Increased the expression of the cyclin kinase inhibitors CDKN1A (p21WAF1) and CDKN1B (p27) in a dose-dependent manner.
Decreased the the expression of the pro-proliferative cell cycle regulators CCND1 (cyclin D1), CCNE1 (cyclin E1) and CDK2.
Suppressed phosphorylation of the kinases upstream of STAT3, including that of JAK2 and TYK2.
In Vivo

Mogroside V (100 mg/kg for Oral administration) transforms to 26 metabolites by the process of dehydrogenation, deoxidation, oxidation and isomerization in type 2 diabetes (T2D) model rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: T2D model rats[2]
Dosage: 100 mg/kg
Administration: Oral gavage (p.o.)
Result: Detected 28 metabolites of mogroside V compared to the blank biological samples.
Displayed larger peak areas of metabolites in T2D rat plasma samples than those in healthy sample.
Molecular Weight

1287.43

Formula

C60H102O29
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@@](CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]1O)O)([H])O[C@@H]1CO[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C3(C)C)([H])C3=CC4)([C@@H](C[C@@]56C)O)[C@]4([H])[C@@]5(CC[C@]6([H])[C@H](C)CC[C@H](C(C)(O)C)O[C@H](O[C@H](CO[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)[C@@H](O)[C@@H]8O)[C@@H]8O[C@]([C@@H]([C@@H](O)[C@@H]9O)O)([H])O[C@@H]9CO)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (77.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (38.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7767 mL 3.8837 mL 7.7674 mL
5 mM 0.1553 mL 0.7767 mL 1.5535 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (1.62 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (1.62 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.01%

COA (259 KB) HNMR (353 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.7767 mL 3.8837 mL 7.7674 mL 19.4185 mL
5 mM 0.1553 mL 0.7767 mL 1.5535 mL 3.8837 mL
10 mM 0.0777 mL 0.3884 mL 0.7767 mL 1.9419 mL
15 mM 0.0518 mL 0.2589 mL 0.5178 mL 1.2946 mL
20 mM 0.0388 mL 0.1942 mL 0.3884 mL 0.9709 mL
25 mM 0.0311 mL 0.1553 mL 0.3107 mL 0.7767 mL
30 mM 0.0259 mL 0.1295 mL 0.2589 mL 0.6473 mL
DMSO 40 mM 0.0194 mL 0.0971 mL 0.1942 mL 0.4855 mL
50 mM 0.0155 mL 0.0777 mL 0.1553 mL 0.3884 mL
60 mM 0.0129 mL 0.0647 mL 0.1295 mL 0.3236 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mogroside V Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mogroside V88901-36-4Reactive Oxygen SpeciesROSmitochondriaType 2 diabetestriterpene glycosideInhibitorinhibitorinhibit

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