2. PROTAC
  3. PROTAC Linkers
  4. N-DBCO-N-bis(PEG2-C2-acid)

N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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N-DBCO-N-bis(PEG2-C2-acid) Chemical Structure

N-DBCO-N-bis(PEG2-C2-acid) Chemical Structure

CAS No. : 2110449-00-6

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25 mg USD 190 In-stock
50 mg USD 310 In-stock
100 mg USD 500 In-stock
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Based on 1 publication(s) in Google Scholar

N-DBCO-N-bis(PEG2-C2-acid) Related Antibodies

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Description

N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-DBCO-N-bis(PEG2-C2-acid) Related Antibodies
Molecular Weight

624.68

Formula

C33H40N2O10
CAS No.
Appearance

Liquid

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N(CCOCCOCCC(O)=O)CCOCCOCCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (200.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6008 mL 8.0041 mL 16.0082 mL
5 mM 0.3202 mL 1.6008 mL 3.2016 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6008 mL 8.0041 mL 16.0082 mL 40.0205 mL
5 mM 0.3202 mL 1.6008 mL 3.2016 mL 8.0041 mL
10 mM 0.1601 mL 0.8004 mL 1.6008 mL 4.0020 mL
15 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6680 mL
20 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0010 mL
25 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
30 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3340 mL
40 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0005 mL
50 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8004 mL
60 mM 0.0267 mL 0.1334 mL 0.2668 mL 0.6670 mL
80 mM 0.0200 mL 0.1001 mL 0.2001 mL 0.5003 mL
100 mM 0.0160 mL 0.0800 mL 0.1601 mL 0.4002 mL
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N-DBCO-N-bis(PEG2-C2-acid) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-DBCO-N-bis(PEG2-C2-acid)2110449-00-6PROTAC LinkersInhibitorinhibitorinhibit

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N-DBCO-N-bis(PEG2-C2-acid)
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