2. Immunology/Inflammation
  3. CD73
  4. Oleclumab

Oleclumab  (Synonyms: MEDI9447)

Cat. No.: HY-P99039 Purity: 99.80%
COA

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Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.

For research use only. We do not sell to patients.

Oleclumab Chemical Structure

Oleclumab Chemical Structure

CAS No. : 1803176-05-7

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Description

Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity[1][2].

In Vivo

Oleclumab (10 mg/kg; ip; every 3 days for 4 doses) increases the proportion of activated CD8+ lymphocyte populations in the mouse Balb/c syngeneic CT26 colon cancer tumor model. And Oleclumab significantly inhibits tumor growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine, Balb/c, syngeneic CT26 colon carcinoma tumor model[2]
Dosage: 10 mg/kg
Administration: ip; 2 time per week, for 2 weeks
Result: Inhibited tumor growth by 50% or greater from study day 7 to study day 16 when compared with isotype control antibody-treated groups.
Clinical Trial
CAS No.
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Liquid

Color

Colorless to light yellow

SMILES

[Oleclumab]
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Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.80%

COA (231 KB)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oleclumab1803176-05-7MEDI9447MEDI 9447MEDI-9447CD73ecto-5′-nucleotidase, NT5Ehuman IgG1λ anti-CD73 monoclonal antibodyanti-tumor activityInhibitorinhibitorinhibit

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