2. Apoptosis
  3. Apoptosis
  4. Pheophorbide A

Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research.

For research use only. We do not sell to patients.

Pheophorbide A Chemical Structure

Pheophorbide A Chemical Structure

CAS No. : 15664-29-6

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Pheophorbide A Related Antibodies

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Description

Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research[1][2][3].

In Vitro

Pheophorbide A (10 µM) increases lymphatic endothelial cells (LECs) sprouting, proliferation and tube formation[1].
Pheophorbide A-mediated photodynamic therapy (Pa-PDT) inhibits cellular growth on Hep3B, in a dose-dependent manner with an IC50 of 1.5 μM[2].
Pheophorbide A (2 µM, 24 h) induces apoptosis in Hep3B cells after photo-activation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pheophorbide A Related Antibodies
In Vivo

Pheophorbide A-mediated photodynamic therapy (Pa-PDT) (10 mg/kg (i.v.) or 30 mg/kg (i.p.)) significantly inhibits tumor growth in C3H mouse model with subcutaneous injection of AT-84 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male immunocompetent C3H mouse (six-week-old, inoculated subcutaneously with AT-84 cells)[3]
Dosage: 10 mg/kg intravenous (i.v.) or a 30 mg/kg intraperitoneal (i.p.) injection
Administration: IV or IP; after 24 h, PDT was performed
Result: Pa-PDT, especially i.v. Pa-PDT, significantly inhibited tumor growth up to 70%, while the i.p. Pa-PDT-induced inhibition was up to 43.4% relative to the control group at the end of period.
Molecular Weight

592.68

Formula

C35H36N4O5
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C([C@@H]1/C(C(NC(/C=C2C(CC)=C3C)=C4C)=C4C1=O)=C(N=C(/C=C(C(C)=C/5C=C)\NC5=C/C3=N/2)[C@H]6C)\[C@H]6CCC(O)=O)OC
Structure Classification
Initial Source

Botrytis cinerea
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (3.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6873 mL 8.4363 mL 16.8725 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥93.0%

COA (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6873 mL 8.4363 mL 16.8725 mL 42.1813 mL
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Pheophorbide A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pheophorbide A15664-29-6ApoptosisE. Perfoliatumlymphatic vascular activatorEupatorium perfoliatumPlant extractLymphangiogenesisLymphatic activatorHepatocellular Carcinoma CellsAT-84 cellsInhibitorinhibitorinhibit

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