PARVA/alpha-Parvin Protein, Human (GST)

PARVA/α-Parvin protein is essential for sarcomere organization and smooth muscle cell contraction. It plays an important role in embryonic cardiovascular development, cardiac outflow tract septation, angiogenesis, and adhesion of vascular smooth muscle cells to endothelial cells during vascular development. PARVA/alpha-Parvin Protein, Human (GST) is the recombinant human-derived PARVA/alpha-Parvin protein, expressed by E. coli , with N-GST labeled tag. The total length of PARVA/alpha-Parvin Protein, Human (GST) is 372 a.a., with molecular weight of ~69 kDa.

PARVA/alpha-Parvin protein is instrumental in sarcomere organization and the contraction of smooth muscle cells. Its significance extends to the normal development of the embryonic cardiovascular system, particularly in the septation of the heart outflow tract. Additionally, it plays a crucial role in sprouting angiogenesis and contributes to the adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. PARVA is actively involved in actin cytoskeleton reorganization, lamellipodia formation, ciliogenesis, cell polarity establishment, adhesion, spreading, and directed cell migration. Its interactions with various proteins, including TGFB1I1, LIMS1, ARHGAP31, ILK, TESK1, and PXN/PAXILLIN, highlight its engagement in intricate cellular processes and signaling pathways.

Human

E. coli

N-GST

Q9NVD7 (M1-E372)

55742  [NCBI]

Approximately 69 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.